Preparation and characteristics of nanostructured lipid carrier nlc loaded red ginger extract using high pressure homogenizer method siti sadiah1,2,3, effionora anwar 1, mahdi djufri, umi cahyaningsih2 1faculty of pharmacy, university of indonesia, indonesia 2faculty of veterinary medicine, bogor agricultural university, indonesia 3tropical biopharmaca research center, bogor agricultural. Open access full text article effect of compositions in. Aug 30, 2012 among the formulations above, the nanostructure lipid carriers nlcs are regarded as the secondgeneration of lipid nanoparticlesthe purpose of this study is to develop an optimized nanostructured lipid carriers nlc formulation for ritonavir, and to estimate the potential of nlc as oral delivery system for poorly watersoluble drugs. Preparation and characteristics of nanostructured lipid. Nlcs, containing mixed lipids solid fat and liquid oil, have many advantages over solid lipid nanoparticles slns. Nanostructure lipid carrier rahul dalvi linkedin slideshare. Lipid nanoparticles are a promising alternative to traditional colloidal drug carriers.
Influence of oil composition on the transformation. Tan, janet sui ling 2020 gastrointestinal mucoadhesion, absorption and biodistribution of orally administered chitosancoated amphotericin b nanostructured lipid carriers nlc formulation. Slns and nlcs are colloidal carriers developed in the last decade as an alternative system to the existing traditional carriers emulsion, liposomes and polymeric nanoparticles. Dacarbazine dac is one of the most commonly used chemotherapy drugs for treating various cancers. Nanostructured lipid carriers have attracted expanding scientific and commercial vigilance in the last couple of years as alternate carriers for the pharmaceutical consignment, particularly anticancer pharmaceuticals. Nano structured lipid carriers nlc, topical drug delivery system, solid. Nanostructured lipid carriers nlcs consist of a solid lipid matrix with a certain amount of liquid lipid, and were introduced as a novel delivery system for various cosmetic active ingredients and pharmaceutical drugs. Pdf in this study, we aimed to investigate the influence of liquid lipid types on different. Classification of nlc based on the nanostructure, composition and ratios of solid and liquid lipids. Nlc disediakan dengan menggunakan lipid pepejal compritol 888 ato, lipid cecair asid oleik, dan surfaktan poloxamer 188 dan tween 80 the aim of the present study was to prepare nanostructured lipid carriers nlcs of lopinavir water insoluble and verapamil. Hot high pressure homogenization with the capability for scale up production was successfully used to manufacture the nanocarriers without the use of toxic organic solvents for the first time. In this paper, we investigated the potential of lipid nanoparticles as carriers for aqueous extract of spirogyra spp. Sudhakar, s 2014 development of simvastatin loaded nanostructured lipid carriers based hydrogels for diabetic wound healing. It also overcomes the disadvantages of various lipid particulate carriers due to the various advantages of.
Nanostructured lipid carriers as a delivery system of tobramycin and ciprofloxacin. It was shown that nlcs reveal some advantages for drug therapy over conventional carriers, including increased solubility, the ability to enhance storage stability, improved permeability and bioavailability, reduced adverse effect, prolonged halflife, and tissue. Slns and nanostructured lipid carriers nlcs are promising delivery systems due to the ease of. Nanostructured lipid carriers as a drug carrier open access. In view of the ineffectiveness of some drug treatments, the surgical removal of cysts remains the preferred treatment option together with the administration of. The larval stage of the tapeworm echinococcus granulosus is the causative agent of hydatid disease in humans. Many compounds with high lipophilic character incorporated into nanostructured lipid carriers nlc have been reported. Nanostructured lipid carriers, curcumin, drug release, cytotoxicity, liquid lipid. The aim of the present study was to encapsulate rutin by nanostructured lipid carriers rnlcs, as a. This study aimed to improve the drug solubility and prolong drug release by developing nanostructured lipid carriers nlcs for dac delivery. Formulation and evaluation of nanostructured lipid.
Potential problems associated with sln namely, limited drug loading, risk of gelation and drug leakage during storage caused by lipid polymorphism have been further minimized by a new generation of lipid systems, the nanostructured lipid carriers nlc developed at the turn of the millennium muller et al. Nanostructured lipid carriers as a drug carrier open. Quercetin loaded nanostructured lipid carriers based gel for rheumatoid arthritis 3969 qct, solid lipid gms and qctnlcs. This thesis explores drug delivery systems based on solid lipids. This study describes the preparation, characterisation and in vitro activity of nanostructured lipid carriers nlcs encapsulating natural molecules with antimicrobial activity, such as plumbagin, hydroquinon, eugenol, alphaasarone and alphatocopherol. Nanostructured lipid carrier system for the treatment for. Nanostructured lipid carriers nlcs are drugdelivery systems composed of both solid and liquid lipids as a core matrix. Response surface method with a threelevel boxbehnken design was.
Nanostructured lipid carriers nlc for the delivery of. Preparation and characterization of nanostructured lipid. Pdf preparation and characterization of nanostructured lipid. It was demonstrated that nlcs uncover a few points of interest for medication treatment conventional carriers, including increased solubility, the ability to enhance storage stability, improved permeability and bioavailability, prolonged halflife, reduced. Lipid nanoparticles have shown promising results and progress are being made in this novel drug delivery system 17,18. Valloaded nlcs were prepared using ultrasonic meltemulsification method. Carvacrol loaded nanostructured lipid carriers as a. The short term stability of efavirenzloaded solid lipid nanoparticle and nanostructured lipid carrier dispersions was investigated.
Among the formulations above, the nanostructure lipid carriers nlcs are regarded as the secondgeneration of lipid nanoparticlesthe purpose of this study is to develop an optimized nanostructured lipid carriers nlc formulation for ritonavir, and to estimate the potential of nlc as oral delivery system for poorly watersoluble drugs. Oleic acidloaded nanostructured lipid carrier inhibits. Design and evaluation of miconazole nitrate loaded. Additionally, this study was focused on the application of nobloaded nlc nobnlc in functional food. The purpose of this research was to formulate lipid nanoparticles lipid emulsions le, nanostructured lipid carriers nlc and polymer coatednlc for delivery of anticancer drug, alltrans retinoic acid atra. Preparation and characterisation of nobiletinloaded. Particle size and physical state of the lipid phase are major factors influencing the permanence of lipid dispersions. Skin cancer, nanostructured lipid carriers, topical drug delivery, drug targeting. Pharm thesis submission, dayanand dinanath college, institute of pharmacy, dr.
Nanostructured lipid carriers of ivermectin as a novel drug. A novel generation of solid lipid drug carriers magdalene radtke is a research scientist at pharmasol gmbh, germany. Nanostructured lipid carrier nlc was prepared by homogenization emulsification method and improved with modified surfactants. The optimized condition of nlc in stirring was 1200 rpm, the homogenized speed was 8000 rpm, solid oil. Design of a nanostructured lipid carrier intended to improve the treatment of tuberculosis marina pinheiro,1, ricardo ribeiro,1, alexandre vieira,1, fernanda andrade,2 salette reis1 11ucibio, requimte, chemistry department, faculty of pharmacy, 2laboratory of pharmaceutical technology, department of drug sciences, faculty of pharmacy, university of porto, porto, portugal these authors. This paper intends to describe briefly the different lipid based. The samples, weighing 2 mg, were analyzed in sealed and pinholed standard 40 l aluminum pans, with a heating rate of 10 ocmin from 30c to 400oc and during the.
The stimulation of glp1 secretion and delivery of glp1. A third generation of lipid matrix was designed as nanostructured lipid carrier nlc is a blend of mixture of solid lipids along with spatially incompatible liquid lipids. Nanostructured lipid carriers of ivermectin as a novel. Pdf design of nanostructured lipid carriers ubiquinone10 for. Encapsulation of ascorbyl palmitate in nanostructured lipid carriers nlc.
Formulation and evaluation of nanostructured lipid carriers. As one of the main types of lipid nanoparticles, nanostructured lipid carriers nlcs act as an alternative carrier system to emulsions, liposomes and polymetric nanoparticles. Nanostructured lipid carriers nlcs for drug delivery and. Solid lipid nanoparticles and nanostructured lipid carriers as novel drug delivery systems. We looked for np answers to the following questions. Sln are produced using solid lipids including highmelting point glycerides. It was shown that nlcs reveal some advantages for drug therapy over conventional carriers, including increased solubility, the ability to enhance storage stability, improved permeability and bioavailability, reduced adverse effect, prolonged halflife, and tissuetargeted. Quercetin loaded nanostructured lipid carriersbased gel.
Natural lipids in nanostructured lipid carriers and its cytotoxicity. Design and evaluation of miconazole nitrate loaded nanostructured lipid carriers nlc for improving the antifungal therapy gajanan s sanap1, guru prasad mohanta2 1department of pharmacy, karpagam university, coimbatore641 021 tamil nadu, india. Nlcs were prepared by melt and ultrasonication method, characterised by cryotem for morphology and sdfff for dimensional. Nanostructured lipid carriers are a new type of delivery system offering improved performance in terms of drug loading and longterm stability with the ability to form highly concentrated dispersions. Phd thesis iron oxide nanoparticles and their toxicological. The objective of this manuscript was to investigate and optimise the potential of nanostructured lipid carriers nlcs as a carrier system for nobiletin nob, which was prepared by highpressure homogenisation method. Nanostructured lipid carriers nlc are one of the promising nanocarriers for the development of effective targeted therapies for cancer chemotherapeutics.
Development of nanostructured lipid carrier for dacarbazine. Development of simvastatin loaded nanostructured lipid. However, hydrophilic compounds have not been completely investigated. These lipid nanoparticles are known as solid lipid nanoparticles slns and nanostructured lipid carriers, which are attracting wide attention of formulators worldwide. Pdf solid lipid nanoparticles and nanostructured lipid. Solid lipids are mixed with liquid lipids preferably in the ratio of 70. Nlcs effectively encapsulated the peptides, the majority of which were only released under the intestinal conditions. Mller rh, petersen rd, hommoss a, pardeike j 2007 nanostructured fat carriers nlc in cosmetic dermal products.
Solid lipid nanoparticles and nanostructured lipid carriers as novel. Tujuan kajian ini adalah untuk menyediakan pembawa lipid nanostruktur nlc lopinavir tidak larutair dan verapamil larut air. However, its poor water solubility, short halflife in blood circulation, low response rate and high side effect limit its application. After a process of preparation, remove solvents in sample by rotary vacuum evaporator at. The main reason for this is related with the wellknown conception that lipids promote oral drug absorption, because they undergo the same physiological mechanisms of food lipid digestion.
Sln are produced using solid lipids including highmelting point glycerides or waxes, replacing liquid lipid. Nanostructured lipid carriers nlc for the delivery of natural molecules with antimicrobial activity. Oleic acidloaded nanostructured lipid carrier inhibits neutrophil activities in the presence of albumin and alleviates skin inflammation chunyu chen,1,2 yinghsuan lee,1 shihhsin chang,1,35 yungfong tsai,1,2 jiayou fang,5 tsonglong hwang,5,61graduate institute of natural products, college of medicine, chang gung university, taoyuan 333, taiwan. Formulation and characterization of nanostructured lipid. Nanostructured lipid carriers nlcbased topical gel of etoricoxib was prepared with the aim. The influences of liquid medium chain triglycerides mct and solid glyceryl tristearate gts contents in the lipid matrix of nanostructured lipid carriers nlcs on their delivering capacities for cur were investigated herein by simulated gastrointestinal tract and caco2 monolayer models. Preparation and characterization of vinpocetine loaded. Nanotechnology having developed exponentially, the aim has been on therapeutic undertaking, particularly for cancerous disease chemotherapy. Herein, we hypothesize that nanostructured lipid carriers nlcs could activate the endogenous glucagonlike peptide1 glp1 secretion and also act as oral delivery systems for glp1 analogs exenatide and liraglutide. Design of a nanostructured lipid carrier intended to. Although cold homogenization minimizes the thermal exposure of the sample, but it cannot be completely avoidable as melting of the lipiddrug mixture is required. Schematic view of the solid lipid nanoparticle sln and nanostructured lipid carriers nlcs showing the drug location. Different production methods which are suitable for large scale production and applications of solid lipid nanoparticles are described. Natural lipids in nanostructured lipid carriers and its.
Development and characterization of lipid nanoparticles. These carrier systems overcome observed limitations of conventional sln. The blends obtained are also solid at room temperature and body temperature. Formulation and characterization of hydroquinone nanostructured. To optimize a nanostructured lipid carriers system nlc for the peroral delivery of valsartan val, a model bcs class ii drug, in an attempt to enhance its therapeutic performance by increasing both solubility and dissolution. Lipidbased nanosystems have great potential for transdermal drug delivery. Englishthis thesis deals with the studies carried out by the writer for the past four years. Preparation and characterization of vinpocetine loaded nanostructured lipid carriers nlc for improved oral bioavailability july 2010 international journal of pharmaceutics 39412. The properties of nanoparticles were investigated using the nlc system for hydroquinone hq as a model drug and by increasing the light stability of hydroquinone. Carvacrol loaded nanostructured lipid carriers as a promising parenteral formulation for leishmaniasis treatment.
Nanostructured lipid carrier nlc was prepared by homogenization emulsification. Solid lipid nanoparticles and nanostructured lipid. Nanostructured lipid carriers nlc are a delivery system in which partialcrystallized lipid particles with mean radii. Topical drug application has been introduced since long time to. Gastrointestinal mucoadhesion, absorption and biodistribution. The synergy between nanostructured lipid carriers nlc and chemical penetration enhancers provides the basis for a promising strategy to effectively deliver drugs through the skin. Appendages such as hairs and glands are derived from, and linked to, the epidermis but project deep into the dermal layer. In the present work, focus is given to the study of the interaction of limonene, ethanol, and carbopol ultrez 10nf, as the gelling agent, with a coencapsulating nlc dispersion, containing both olanzapine and. Full text design of a nanostructured lipid carrier intended. Professor luis joaquim pina da fonseca professor jorge humberto gomes leitao. Nanostructured lipid carriers nlcs are drugdelivery systems and they are made out of solid and fluid lipids as a core matrix.
This thesis is dedicated to my parents, who have given me invaluable. The purpose of this study was to develop an optimised formulation for a nanostructured lipid carrier nlc loaded with. Solid lipid nanoparticles and nanostructured lipid carriers. Solid lipid nanoparticles sln and nanostructured lipid carriers nlc structural investigations on two different carrier systems.
Lipid nanoparticles are colloidal carriers which have shown a high potential as a suitable drug carrier because of their. It is foreseen that, in the beside future, nanostructured lipid carriers will be further advanced to consign cytotoxic anticancer compounds in a more. Nov 20, 2012 nanotechnology having developed exponentially, the aim has been on therapeutic undertaking, particularly for cancerous disease chemotherapy. These biocompatible andor biodegradable lipids based nanoparticles are composed of solid and liquid lipids as a core matrix dispersed in surfactant solution.
This zoonotic parasitic infection remains a major health problem in certain areas of the world where is still endemic. Produced from blends of solid lipids and liquid lipids. Masters thesis, college of pharmacy, madurai medical college, madurai, tamil nadu, india. Nov 20, 2012 solid lipid nanoparticles sln and nanostructured lipid carriers nlc in cosmetic and dermatological preparations. Nanostructured lipid carriers nlc are one of the promising nano carriers for the development of effective targeted therapies for cancer chemotherapeutics. Preparation and characterization of minoxidil loaded.